What is "the wine of the wrath of her fornication"?

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Revelation 14:8 And there followed another angel, saying, Babylon is fallen, is fallen, that great city, because she made all nations drink of the wine of the wrath of her fornication.

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What is the wrath referring to?

The 2 words, "her fornication", can be understood

What does, "the wrath of her fornication", mean?