I may have mentioned this before, I’m sorry if I did, & forgot:

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Revelation 16:2 And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image.

(The first angel went and poured out his vial upon the earth, not on a specific nation or kingdom.

Apparently, because the recipients of the wrath of God are in various places and nations of the earth.

The recipients, here, are those who had the mark of the beast, and those who had worshipped his image.

The wrath falls upon them by way of a sore, presumably an open wound, which is grievous and noisome:

noisome: noxious to health, injurious, hurtful, destructive, offensive to the smell or other senses, rancid scent, disgusting

grievous: afflictive, painful, hard to bear, causing grief or sorrow, distressing, great and atrocious

sore: a place where the skin and flesh are ruptured or bruised, painful

It doesn’t say where on the body the sore is, but since it is noisome, it must be obvious to others, by smell, or by sight.

The mark had identified them with the antichrist, to those around them.

Now, their painful, foul smelling sore also identifies them with the antichrist, to those around them.

Even the image worshippers, which were much more low-key publicly, now are openly identified with the antichrist.

People will suffer with the pain from the sore, but also by being so offensive to others, the others won’t want to be around them.

The mark had allowed them to buy or sell, but now they might not be allowed in places, if the offense is bad enough.

Now they are the outcasts, now they are alone, now they are persecuted.

It’s too late for them, they already took the mark, so what’s going on here?

This is open and before men and angels, to know that Jesus’ wrath is based on his righteousness.

Also, this is an extreme demonstration of :)

I Timothy 5:20 Them that sin rebuke before all, that others also may fear.

Deuteronomy 19:20 And those which remain shall hear, and fear, and shall henceforth commit no more any such evil among you.

Acts 19:17 And this was known to all the Jews and Greeks also dwelling at Ephesus; and fear fell on them all, and the name of the Lord Jesus was magnified.

(So that others do not take the mark during the time remaining.

The world had been warned about the mark by the flying angel, who warned of fire and brimstone.

The sore, now, warns others that the fire and brimstone is not a metaphor, or simply a story, but is as real as the sore is.)