People will (fall away from) rebel against God. Then "before the Lord returns," the wicked one (Antichrist) who is doomed to be destroyed will appear........ (2 Thessalonians 2:3)

He (Antichrist) will speak out against the Most High and.... "oppress THE SAINTS" of the Most High, intending to change the appointed times and laws; and......

"THE SAINTS" will be.... "given into his hand" (not God's wrath) for a time, and times, and half a time. (Daniel 7:25)